Fecal Pancreatic Elastase-1
Pancreatic elastase-1 is an enzyme made by your pancreas that passes through the gut largely unchanged, so its level in stool reflects how well the pancreas is producing digestive enzymes.
This test is a key way to check for exocrine pancreatic insufficiency, a state where the pancreas doesn't make enough enzymes to digest food properly. It helps explain symptoms like greasy stools, bloating, weight loss, or poor nutrient absorption.
Higher levels are generally considered normal and reassure that the pancreas is producing enzymes well. Unusually high values are not typically a clinical concern on their own, though results should always be read in context.
This test is inverse: a LOW level suggests pancreatic insufficiency, meaning the pancreas may not be making enough digestive enzymes. Lower results point toward more significant insufficiency and warrant follow-up with a clinician.
A result comfortably within the normal range is generally reassuring, but reference cutoffs vary by lab. Your clinician can interpret a low result alongside your symptoms and other tests.
Sources
Educational context only, not medical advice or a diagnosis. Reference ranges vary by lab, age and sex; always discuss your results with a clinician.