SupplementsVitaminsMethyl B-Complex
Methyl B-Complex
with 5-MTHF and methylcobalamin
All your B vitamins, in their active forms, including the two your methylation runs on.
- Builds up
- Weeks
- In your body
- Varies by vitamin
- Per 1 vegan capsule
- 9 ingredients
- 30-day supply
- $6.60One capsule a day, plus packing and delivery
What is a methyl B-complex?
B vitamins help your cells make energy, build DNA and keep nerves working. Your body doesn't store most of them for long.
Ours uses active forms: 5-MTHF for folate, methylcobalamin for B12, and P5P for B6, along with benfotiamine, riboflavin, niacin, biotin and pantothenic acid.
What it does
- EnergyHelps turn food into energy.
- NervesSupports normal nerve function.
- Red blood cellsFolate and B12 support healthy red blood cell formation.
- MethylationSupports normal homocysteine metabolism.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
What people take it for
Good evidence
Some evidence
MixedHow long it takes
Levels rise over a few weeks. If you were low, a repeat blood test will show it.
- Hours to daysWhat you don't use leaves in your urine
- WeeksYour blood levels and homocysteine start to move
- Months to yearsHow long B12 stores take to build or run down
How long it stays in your body
Most B vitamins leave your body quickly, so you need them regularly. B12 is the exception: your liver can store it for years.
What's in a capsule
One capsule holds 400 mcg of folate and 500 mcg of B12, plus the rest of the B family.
Methylation and MTHFR
Think of methylation as your body passing small tags from one molecule to another. It's how it clears homocysteine, and it helps with DNA, nerves and mood. Folate and B12 do the passing, and B6 clears homocysteine another way.
MTHFR is the gene behind this. A common variant slows it down, and two copies are found in about 25% of Hispanic people, 10% of Caucasian and Asian people, and 1% of African American people. Ours uses folate that's already active (5-MTHF), so your body skips that step, and how that compares with a regular B-complex is in the full guide.
One important exception: if you could become pregnant, the CDC recommends folic acid rather than 5-MTHF, even with this variant. Ask your doctor.
What it interacts with
- MethotrexateFolate can get in the way when it's used for cancer. Ask your doctor first.
- Epilepsy medicinesThey can lower your folate, and folate might lower the medicine.
- SulfasalazineIt lowers how much folate you absorb.
- Metformin and acid-reducing medicinesThey can lower your B12 over time, so it's worth checking.
- Blood testsThe biotin in this can throw off some tests, including thyroid. Tell your doctor or the lab you take it.
Goes well with
Side effects
- Bright yellow urine is normal and harmless. It comes from riboflavin.
- Niacin can sometimes cause a brief warm flush.
Check first if
- Trying to conceive or pregnant: ask your doctor about folic acid, and whether this fits.
- Before blood tests: mention the biotin.
- Folate can hide low B12, so get tested if you have numbness or tingling.
The blood tests that go with it
Supplementation
Find Methyl B-Complex in a ready-made protocol.
Start from one of these, or add it to your own. Everything comes in one pouch each morning.
Mind & balance
For a demanding day.
30-day pack · 6 a morning · 180 pills
$75.30 / month
Choose this packBody & skin
Put heart health in focus.
30-day pack · 7 a morning · 210 pills
$84.54 / month
Choose this packMind & balance
Make space for balance.
30-day pack · 6 a morning · 180 pills
$73.50 / month
Choose this packLife stages
A broader daily foundation.
30-day pack · 7 a morning · 210 pills
$92.29 / month
Choose this packDaily foundations
For a plant-based routine.
30-day pack · 7 a morning · 210 pills
$86.10 / month
Choose this packYour own
Build your own pouch.
Know what you want to take? Pick each ingredient, and we time it through your day.
Build your own
- cGMP-certifiedFacilities
- FDA-registeredFacilities
- Accredited labsIndependent testing
- Non-GMOIngredient options
- OrganicIngredient options
- VeganFormula options
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Want it more precise? Get the app.
A page can only tell you about Methyl B-Complex. The app tells you about you: whether it fits, when to take it, and whether it's working.
- Checked against your blood work and everything you already take
- On your daily timeline, around your sleep, training and meals
- Followed over time, so you can see what moved
Methyl B-ComplexOPEN 09:00Methyl B-Complex against your blood work, your sleep and what you already take.
AIYour homocysteine came down since your last test. Your B12 is in range too.
ASK ABOUT METHYL B-COMPLEXFind the goal that's yours.
Your record, your routine and LifeFrom AI, pointed at the outcome that matters to you.
Questions
What is a methylated B-complex?
It uses active forms of folate and B12, so your body has less converting to do.
What does methylation do?
It's how your body passes small tags between molecules, to clear homocysteine and support your DNA and nerves.
Is it okay before pregnancy?
Ask your doctor first. The CDC recommends folic acid for anyone who could become pregnant, even with the MTHFR variant.
Why did my urine turn yellow?
That's riboflavin, and it's harmless.
Sources
- NIH Office of Dietary Supplements. Folate: fact sheet for health professionals.
- NIH Office of Dietary Supplements. Vitamin B12: fact sheet for health professionals.
- Li D et al. Association of biotin ingestion with performance of hormone and nonhormone assays in healthy adults. JAMA, 2017.
Written by LifeFrom from these sources, and not yet reviewed by a clinician. Talk to your doctor before starting a supplement.
