SupplementsHerbs & MushroomsMushroom Immune
Mushroom Immune
a blend of 14 mushroom mycelia
Fourteen mushrooms in one capsule, grown as fine root-like threads instead of caps, for people who want a broad daily immune habit.
- Builds up
- About 4 weeks
- In your body
- Not known
- Per 1 capsule
- 15 ingredients
- 30-day supply
- $10.20One capsule a day, plus packing and delivery
What is mushroom immune?
Mushrooms have a long place in traditional medicine across Asia, and several in this blend are household names: reishi, turkey tail, chaga, maitake, shiitake and cordyceps. They share a family of long sugar chains called beta-glucans, which your immune cells can recognize.
This blend holds 14 in all. Alongside those six you get lion's mane, poria, fomes, agaricus, mesima, tremella, velvet foot and zhu ling.
Every one is in the form of mycelia, the network of threads a mushroom grows from, rather than the cap and stem you'd see in a shop. These are ordinary functional mushrooms. None is psychedelic.
What it does
- Immune systemSupports the normal work of your immune cells.
- Inflammatory responseHelps maintain a healthy inflammatory response.
- Daily balanceTraditionally used to support general wellbeing.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
What people take it for
Early daysImmune supportPeople who ate 5 to 10 g of dried shiitake daily for 4 weeks had more active immune cells. That's food amounts of one mushroom, not this blend.
Early daysLow-level inflammationThe same shiitake study saw CRP, a blood sign of inflammation, come down.
Early daysStress and moodIn young women, a lion's mane and reishi mix eased anxiety more than lion's mane alone. It's one small study of a different product.
How long it takes
This isn't something you'd feel. The main food study saw immune cells change after 4 weeks of daily use, so think in weeks and months.
- First daysDon't expect to feel anything. It works quietly, if it works for you
- 4 weeksWhen eating shiitake daily changed immune cells in healthy adults
- MonthsLonger use has barely been studied, so a check-in with your doctor makes sense
How long it stays in your body
There's no clean number for a blend of 14 mushrooms. Much of the action is thought to start in your gut, rather than from anything building up in your blood.
What's in a capsule
One capsule holds 525 mg, shared across all 14 mushrooms. The label doesn't say how it's split. Shared evenly, that would be under 40 mg of each, far less than the grams used in most mushroom studies.
Threads versus caps, and why it matters
Which part of the mushroom is in a product, the threads or the caps, and why threads grown on grain matter, is in the full guide. Our label lists mycelia and a capsule, and doesn't say what they were grown on.
You may also read that turkey tail is a cancer medicine in Japan. A specific purified extract called PSK is used there alongside standard care, and that's a very different thing from a small share of turkey tail threads in a daily blend.
What it interacts with
- Warfarin and other blood thinnersOne person on warfarin had a raised clotting number, INR, with maitake extract. Reishi and cordyceps may also raise bleeding risk, and one person bled heavily after a tooth extraction on daily cordyceps. Ask first, and expect closer checks.
- Diabetes medicines and insulinMaitake and cordyceps may lower blood sugar further. Tell your doctor before you start.
- Surgery and dental workBecause of that bleeding risk, tell your care team you use this.
- Immune-suppressing medicinesMushrooms can stir up immune cells, which could work against these medicines, including those after a transplant.
- Cancer treatmentMushrooms are popular during cancer care, but agaricus has been linked to severe liver damage in patients. Speak to your care team first.
- AlcoholA man developed sudden liver inflammation after reishi powder and alcohol together. He recovered, but it's worth knowing.
- Our Lion's Mane and CordycepsThis blend already holds a small amount of both.
Goes well with
Side effects
- Usually mild: nausea, diarrhea or muscle aches.
- Allergic reactions, as with any mushroom.
- Rarely, liver problems have been reported with reishi and agaricus. Stop and call your doctor if you notice yellow skin or eyes, or dark urine.
- Kidney harm has been reported with chaga, which is rich in oxalate, a natural compound that can form crystals in the kidneys. One man used 3 g of powder a day for 4 years, then 9 g for another. Another used 10 to 15 g a day for 3 months. Those amounts are far above what's in this capsule.
Check first if
- Mushroom allergy: skip it.
- Blood thinners, bleeding problems or upcoming surgery: ask first.
- Diabetes: watch your sugar and tell your doctor.
- Autoimmune conditions or a transplant: ask first, because it may stir up your immune system. Reishi has been linked to flares of autoimmune skin disease.
- Myeloid blood cancers: this blend holds cordyceps, which experts advise against here.
- Kidney disease or kidney stones: ask first, because of the chaga.
- Liver disease: ask first.
- Cancer care: talk to your care team.
- Pregnancy or breastfeeding: there isn't enough safety data, so check with your doctor.
The blood tests that go with it
- White blood cellsYour overall immune cell count, on any routine blood test.
- LymphocytesThe immune cells that became more active in the shiitake study.
- hs-CRPShows low-level inflammation. It fell in that same study.
- ALTA simple liver check, given the rare reports with reishi and agaricus.
- CreatinineA kidney check, because chaga is high in oxalate.
- INRYour clotting number, if you take warfarin. Reishi extracts may lengthen clotting results too.
- Fasting glucoseMaitake and cordyceps may lower blood sugar.
- HbA1cYour blood sugar over about three months, if you manage yours with medicine.
Work it out
Supplementation
Or start from a ready-made protocol.
Start from one of these, or add it to your own. Everything comes in one pouch each morning.
Mind & balance
For your focused hours.
30-day pack · 5 a morning · 150 pills
$70.35 / month
Choose this packMind & balance
For a demanding day.
30-day pack · 6 a morning · 180 pills
$75.30 / month
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A skin-focused routine.
30-day pack · 6 a morning · 180 pills
$75.42 / month
Choose this packBody & skin
Put heart health in focus.
30-day pack · 7 a morning · 210 pills
$84.54 / month
Choose this packDaily foundations
Start with your gut.
30-day pack · 6 a morning · 180 pills
$98.70 / month
Choose this packBody & skin
A bone-focused foundation.
30-day pack · 6 a morning · 180 pills
$84.88 / month
Choose this packBody & skin
For an active life.
30-day pack · 5 a morning · 150 pills
$75.40 / month
Choose this packMind & balance
Make space for balance.
30-day pack · 6 a morning · 180 pills
$73.50 / month
Choose this packDaily foundations
Four mineral building blocks.
30-day pack · 4 a morning · 120 pills
$62.10 / month
Choose this packDaily foundations
An antioxidant-focused stack.
30-day pack · 6 a morning · 180 pills
$86.22 / month
Choose this packLife stages
Your everyday starting point.
30-day pack · 6 a morning · 180 pills
$79.62 / month
Choose this packLife stages
A broader daily foundation.
30-day pack · 7 a morning · 210 pills
$92.29 / month
Choose this packDaily foundations
For a plant-based routine.
30-day pack · 7 a morning · 210 pills
$86.10 / month
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Build your own pouch.
Know what you want to take? Pick each ingredient, and we time it through your day.
Build your own
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- FDA-registeredFacilities
- Accredited labsIndependent testing
- Non-GMOIngredient options
- OrganicIngredient options
- VeganFormula options
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Want it more precise? Get the app.
A page can only tell you about Mushroom Immune. The app tells you about you: whether it fits, when to take it, and whether it's working.
- Checked against your blood work and everything you already take
- On your daily timeline, around your sleep, training and meals
- Followed over time, so you can see what moved
Mushroom ImmuneOPEN 09:00Mushroom Immune against your blood work, your sleep and what you already take.
AIYou've caught two colds since September, and your white cells looked normal in June. Want to check your vitamin D too?
ASK ABOUT MUSHROOM IMMUNEFind the goal that's yours.
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Questions
What are mushroom supplements good for?
Mostly immune support, along with inflammation and general wellbeing. Evidence in healthy people is early, and most of it looks at one mushroom at a time.
How long does a mushroom blend take to work?
Think weeks. In the main food study, immune cells changed after 4 weeks of daily shiitake. You probably won't feel a difference day to day.
What are the side effects of mushroom supplements?
Usually mild stomach upset or muscle aches. Rarely, reishi and agaricus have been linked to liver problems, and large amounts of chaga to kidney problems.
Who should not take mushroom supplements?
Anyone with a mushroom allergy or a myeloid blood cancer. Ask first if you take blood thinners, diabetes medicines or immune-suppressing medicines, have kidney or liver disease, an autoimmune condition or cancer, have surgery coming up, or are pregnant.
Are these mushrooms psychedelic?
No. None of these 14 is a psychedelic mushroom, and they won't make you feel high.
Can I take a mushroom blend every day?
That's how it's generally used, though long-term use hasn't been studied much in blends like this. If you plan to stay on it, include your liver and kidney numbers in your regular blood tests.
Is chaga safe for your kidneys?
In ordinary amounts, serious problems look rare. Chaga is high in oxalate, and people have had kidney damage after using several grams of powder a day for months or years. This capsule holds only a small share of chaga.
Does it help with cancer?
This blend isn't a cancer product. Some mushroom extracts are studied alongside cancer care, but experts say the evidence is too thin to recommend them routinely. Please talk to your care team.
Sources
- Dai X et al. Consuming Lentinula edodes (shiitake) mushrooms daily improves human immunity. J Am Coll Nutr, 2015.
- Berger RG et al. Mycelium vs. fruiting bodies of edible fungi: a comparison of metabolites. Microorganisms, 2022.
- Windsor C et al. Comparative study of chaga dietary supplements using complementary analytical techniques. Int J Mol Sci, 2025.
- Smith EF, Docherty S. Four-week supplementation of lion's mane and a lion's mane and reishi blend on mood and wellbeing in young women. Front Nutr, 2026.
- National Cancer Institute. Medicinal mushrooms (PDQ).
- Narayanan S et al. Medicinal mushroom supplements in cancer: a systematic review of clinical studies. Curr Oncol Rep, 2023.
- Hanselin MR et al. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother, 2010.
- Mukai H et al. Agaricus blazei may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol, 2006.
- Guedikian R et al. Reishi mushroom-induced acute liver injury in the setting of alcohol use. Cureus, 2023.
- Yuen MF et al. Hepatotoxicity due to a formulation of Ganoderma lucidum. J Hepatol, 2004.
- Lee S et al. Development of end stage renal disease after long-term ingestion of chaga mushroom. J Korean Med Sci, 2020.
- Kwon O et al. Chaga mushroom-induced oxalate nephropathy. Medicine, 2022.
- Memorial Sloan Kettering Cancer Center. Reishi mushroom.
- Memorial Sloan Kettering Cancer Center. Maitake.
- Memorial Sloan Kettering Cancer Center. Cordyceps.
Written by LifeFrom from these sources, and not yet reviewed by a clinician. Talk to your doctor before starting a supplement.
